TB bly een van die grootste oorsake van sterftes by kinders w\u00eareldwyd en eis die meeste lewens van kinders jonger as vyf jaar.<\/p>\n\n\n\n
\u2019n Rigtinggewende kliniese proef, wat verlede week op die vergadering van die Union Conference on Lung Health in Parys bekend gestel is, het getoon dat \u2019n orale antibiotika, wat een keer per dag vir ses maande geneem word, die risiko om middelweerstandige TB te ontwikkel aansienlik verminder. <\/p>\n\n\n\n
Die antibiotikum levofloksasien het die risiko van multimiddelweerstandige (MDR) tuberkulose (TB) by kinders met 56% verminder, het navorsers van die Desmond Tutu TB-sentrum (DTTS) by die Universiteit Stellenbosch (US) se fakulteit geneeskunde en gesondheidswetenskappe (FGGW) aangekondig. Die Unitaid-gefinansierde proef het voorts getoon levofloksasien, wat een keer per dag aan kinders ouer as ses maande gegee word, is uiters veilig.<\/p>\n\n\n\n
Bewyse oor voorkomende behandeling vir MDR-TB was tot nou beperk omdat ewekansig beheerde proewe nog nooit gedoen is nie. TB-CHAMP het in Suid-Afrika plaasgevind, in ses navorsingsterreine in vyf provinsies wat gemeenskappe met \u2019n ho\u00eb TB- en MDR-TB-las bedien, en het hoofsaaklik op kinders jonger as vyf jaar gefokus. <\/p>\n\n\n\n
\u201cDaar was baie vooruitgang in die wetenskap rondom die voorkoming van middelvatbare TB, maar baie min streng data oor die voorkoming van dwelmweerstandige TB,\u201d s\u00ea prof. Anneke Hesseling, direkteur van die DTTS en die algehele hoofondersoeker van die TB-CHAMP-proef aan die US. <\/p>\n\n\n\n
\u201cOns het nou \u2019n manier gevind om kinders veilig te hou wanneer \u2019n volwassene in die huishouding MDR-TB het. Die belang daarvan om ons kinders teen middelweerstandige siektes te beskerm, kan nie onderskat word nie. Die voordeel vir kinders, hul gesinne en gemeenskappe kan aansienlik wees.\u201d<\/p>\n\n\n\n
\u201cMDR-TB is een van die moeilikste siektes om te genees en kinders was nog altyd die mees verwaarloosde pasi\u00ebnte,\u201d s\u00ea prof. James Seddon, mede-hoofondersoeker van TB-CHAMP van die US. \u201cDeur \u2019n nuwe manier te vind om kinders veilig te hou wanneer MDR-TB \u2019n familielid raak, help ons die hele gesin om soveel vinniger te herstel van die trauma wat die siekte veroorsaak \u2013 nie net uit \u2019n gesondheidsperspektief nie, maar ook uit ekonomiese en geestesgesondheidsperspektiewe.\u201d<\/p>\n\n\n\n
\u201cNavorsing om tuberkulose by kinders te voorkom en te behandel, suig al te lank aan die agterspeen,\u201d het dr. Philippe Duneton, \u2019n uitvoerende direkteur van Unitaid, die grootste multilaterale finansier van TB-navorsing en -ontwikkeling w\u00eareldwyd, ges\u00ea. \u201cUnitaid is bly om deel te wees van pogings om groter aandag aan kinders se behoeftes te gee. Hierdie bewyse in die voorkoming van middelweerstandige TB by kinders, wat \u2019n eerste in sy soort is, behels groot vooruitgang wat die potensiaal het om miljoene kinders teen \u2019n aftakelende siekte te beskerm.\u201d <\/p>\n\n\n\n
In die TB-CHAMP-proef is 453 kinders wat aan \u2019n volwassene met MDR-TB in hul huishouding blootgestel is, levofloksasien toegedien en slegs vyf het MDR-TB ontwikkel. Die medikasie het baie min newe-effekte gehad. Veral gewrigspyn en tendinitis, tradisioneel \u2019n bekommernis, het baie min voorgekom by kinders wat levofloksasien ontvang het.<\/p>\n\n\n\n
TB bly een van die grootste oorsake van sterftes by kinders w\u00eareldwyd en eis van die meeste lewens van kinders jonger as vyf jaar. Na raming ontwikkel 30 000 kinders jonger as 15 jaar jaarliks MDR-TB. Dit is ingewikkeld om met huidige medikasie te behandel omdat dit baie newe-effekte het. Die behandelingskoste vir gesinne en gesondheidsdienste is ook hoog.<\/p>\n\n\n\n
Minder as 20% van kinders met MDR-TB word tans w\u00eareldwyd gediagnoseer en behandel. Dit maak hulle een van die mees verwaarloosde bevolkingsgroepe wat deur TB geraak word. Baie van hierdie kinders was in noue kontak met iemand met aansteeklike MDR-TB, en om hierdie kinders te identifiseer, hulle vir TB te sif en voorkomende behande\u00adling te bied, sal van deurslaggewende belang wees om gevalle op te spoor en MDR-TB by kinders te voorkom.<\/p>\n\n\n\n
\u2019n Raadgewende komitee van die W\u00eareldgesondheidsorganisasie sal in Desember nuwe riglyne vir voorkomende behandeling van MDR-TB oorweeg. Die data van die TB-CHAMP- en ander proewe word beskikbaar gestel om rigting te te bied oor hoe hierdie beraadslagings tot nuwe aanbevelings vir kinders, adolessente en volwassenes kan lei. Die TB-CHAMP-proef is deur Unitaid gefinansier, wat onder die BENEFIT Kids-projek aan die US val. Unitaid versnel toegang tot innoverende gesondheidsprodukte en l\u00ea die grondslag vir die verhoogde gebruik daarvan deur lande en vennote. Die proef is ook deur die Suid-Afrikaanse Mediese Navorsingsraad en die UKRI Medical Research Council deur middel van \u2019n proeftoewysing aan die US gefinansier, met ondersteuning van die Departement van Gesondheid en Maatskaplike Dienste, die Foreign, Commonwealth & Development Office, die Global Challenges Research Fund, die Medical Research Council en Wellcome, as deel van die EDCTP2-program wat deur die Europese Unie ondersteun word.<\/p>\n","protected":false},"excerpt":{"rendered":"
TB bly een van die grootste oorsake van sterftes by kinders w\u00eareldwyd en eis die meeste lewens van kinders jonger as vyf 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