Servikale kanker is steeds die vierde mees algemene kanker by vroue w\u00eareldwyd en \u2019n groot gesondheidsuitdaging.<\/p>\n\n\n\n
Meer as 90% van sterftes kom in lae- en middelinkomstelande (LMIL) voor, met Afrika suid van die Sahara as een van die streke wat die swaarste getref word. <\/p>\n\n\n\n
Servikale kanker, wat ontwikkel as gevolg van \u2019n langtermyninfeksie met die menslike papillomavirus (MPV), is die grootste oorsaak van kankersterftes onder vroue in Suid-Afrika, ten spyte van vooruitgang in vroe\u00eb opsporing en voorkoming.<\/p>\n\n\n\n
\u201cHoewel daar \u2019n verskuiwing van selgebaseerde servikale kankersifting na MPV-DNS-sifting plaasgevind het, is laasgenoemde as sulks dikwels nie spesifiek genoeg om klinies bruikbare resultate te lewer om vroue te identifiseer wat die risiko loop om servikale siekte te ontwikkel nie,\u201d s\u00ea dr. Robyn Adams.<\/p>\n\n\n\n
Sy het onlangs haar doktorsgraad in verloskunde en ginekologie aan die Universiteit Stellenbosch verwerf. Die titel van haar PhD-studie was \u201cExploring options for the secondary prevention of cervical cancer in South Africa\u201d.<\/p>\n\n\n\n
Adams het ondersoek ingestel na die gebruik van \u2019n chemiese proses bekend as DNS-metilering as \u2019n molekul\u00eare toets om sorg in MPV-siftingsprogramme te prioritiseer, veral vir vroue wat met MIV leef en positief getoets word vir sekere ho\u00ebrisiko-MPV-tipes, maar nie direkte verwysing vir behandeling ontvang nie. Vroue wat met MIV leef, loop \u2019n groter risiko vir aanhoudende ho\u00ebrisiko-MPV-infeksies en servikale kanker weens verswakte immuunstelsels.<\/p>\n\n\n\n
Volgens Adams bied DNS-metilering \u2019n potensi\u00eble oplossing om die spesifisiteit van MPV-sifting te verbeter. \u201cDie DNS-metileringsmerkertoets werk deur spesifieke veranderings in die DNS van servikale selle op te spoor. Hierdie veranderings, bekend as metilering, vind plaas wanneer metielgroepe of \u2018etikette\u2019 by sekere dele van die DNS gevoeg word. Hierdie \u2018etikette\u2019, wat soos skakelaars optree, kan be\u00efnvloed hoe gene geaktiveer word om die instruksies in die DNS te lees om prote\u00efene te maak wat die selle help om hul werk te doen.<\/p>\n\n\n\n
\u201cWanneer MPV-infeksie veranderings in die servikale selle veroorsaak, kan dit tot abnormale DNS-metileringspatrone lei. Die toets fokus op twee belangrike biologiese aanwysers wat al bewys is dat dit met die teenwoordigheid en erns van servikale siektes, insluitend servikale kanker, geassosieer word,\u201d verduidelik sy.<\/p>\n\n\n\n
Adams s\u00ea hierdie toets is uniek omdat dit, anders as tradisionele metodes soos selkontroles wat na abnormale selle soek, veranderings in die DNS teiken wat vroe\u00ebr in die siekte plaasvind, wat dit moontlik maak om klinies beduidende MPV-geassosieerde servikale abnormaliteite op te spoor wat meer geneig is om tot kanker te oor te gaan.<\/p>\n\n\n\n
\u201cDeur hierdie vroe\u00eb molekul\u00eare veranderings op te spoor, bied DNS-metileringstoetsing \u2019n meer akkurate manier om vroue te identifiseer wat \u2019n groter risiko het om servikale kanker te ontwikkel. Dit is veral belangrik in gebiede waar vertraagde toegang tot behandeling en opvolgsorg \u2019n uitdaging is.<\/p>\n\n\n\n
\u201cWanneer dit saam met MPV-toetsing gebruik word, bied dit \u2019n meer akkurate manier om te bepaal of \u2019n MPV-infeksie waarskynlik beduidende siektes sal veroorsaak en of dit net \u2019n tydelike infeksie is wat nie onmiddellike ingryping vereis nie.\u201d <\/p>\n\n\n\n
Sy voeg by dat hierdie toets ook uitgevoer kan word op dieselfde monster wat vir MPV-toetsing gebruik word \u2013 hetsy dit nou deur \u2019n gesondheidsorgwerker of deur die vrou self geneem word.<\/p>\n\n\n\n
Adams wys egter daarop dat hoewel die toets vroue met servikale probleme korrek ge\u00efdentifiseer het, dit ook \u2019n groot aantal ongeldige resultate opgelewer het, wat in sommige gevalle nie duidelike antwoorde gebied het nie.<\/p>\n\n\n\n
Terwyl navorsing oor hierdie onderwerp voortduur, beveel Adams aan dat Suid-Afrika sy nasionale beleid vir die voorkoming van servikale kanker met die riglyne van die W\u00eareldgesondheidsorganisasie (WGO) belyn, wat MPV-DNS-toetsing as die goue standaard vir prim\u00eare sifting prioritiseer.<\/p>\n","protected":false},"excerpt":{"rendered":"
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