Twee uit drie adolessente by wie pulmonale tuberkulose (TB) gediagnoseer is, ervaar longabnormaliteite selfs nadat hulle die behandeling vir di\u00e9 siekte suksesvol voltooi het.<\/p>\n\n\n\n
Hierdie onrusbarende bevinding is onthul in \u2019n nuwe studie deur navorsers van die Universiteit Stellenbosch (US), wat onlangs in die prominente mediese joernaal, The Lancet\u2019s series; eClinicalMedicine<\/i>, gepubliseer is. Dit is die eerste studie wat longfunksie in adolessente met TB omvattend geassesseer het tydens anti-TB-behandeling en n\u00e1 voltooiing van behandeling.<\/p>\n\n\n\n
\u201cMin is bekend oor post-TB-longsiekte by adolessente,\u201d verduidelik die studieleier, dr. Marieke van der Zalm, by die US se Desmond Tutu TB-sentrum. \u201cOns data dui daarop dat \u2019n groot deel van adolessente \u2019n verswakte longfunksie het n\u00e1 suksesvolle voltooiing van TB-behandeling. Strategie\u00eb word vereis om individue met \u2019n risiko vir respiratoriese morbiditeit te identifiseer en intervensies is nodig om longgesondheid n\u00e1 TB te verbeter.\u201d<\/p>\n\n\n\n
Elke jaar ontwikkel \u2019n geraamde 850 000 adolessente tuberkulosesiekte, waarvan ongeveer 90% in lae- en middelinkomstelande woon. Adolessensie is \u2019n belangrike tydperk vir longgroei en respiratoriese siektes, soos TB, kan moontlik inmeng met normale longontwikkeling. Tuberkulose tydens adolessensie kan dus \u2019n iemand se vermo\u00eb om volle longpotensiaal te bereik, negatief be\u00efnvloed.<\/p>\n\n\n\n
\u201cMet die kombinasie van die ho\u00eb TB-las, die erns van TB-siekte, sommige gedragsaspekte (insluitend rook), en die kritieke tydperk in longontwikkeling, kan adolessente meer TB-geassosieerde respiratoriese morbiditeit h\u00ea in vergelyking met volwassenes,\u201d waarsku Van der Zalm. \u201cMet \u2019n langer lewensverwagting n\u00e1 TB in vergelyking met volwassenes, kan adolessente aansienlik bydra tot die algehele ongeskiktheidslas wat deur TB veroorsaak word.\u201d<\/p>\n\n\n\n
Die studie is in Kaapstad, Suid-Afrika, gedoen en het 100 adolessente tussen die ouderdomme van 10 en 19 jaar ingeskryf. Die studie het die longfunksie van 50 adolessente wat met TB gediagnoseer is, vergelyk met di\u00e9 van 50 gesonde adolessente wat aan TB blootgestel is, maar nie siekte ontwikkel het nie. Die groep wat met TB gediagnoseer is, het \u2019n reeks longfunksietoetse (spirometrie, plethysmografie, diffusiekapasiteit longfunksie en ses minute looptoets) twee maande nadat anti-TB behandeling begin is, en weer na die voltooiing van behandeling, gemiddeld \u2019n jaar later, uitgevoer. Resultate van die eerste assessering (wat twee maande n\u00e1 behandeling uitgevoer is) het abnormale longfunksie onder 76% van adolessente gevind, en 65% het steeds abnormale longfunksie getoon by die tweede assessering wat uitgevoer is na suksesvolle voltooiing van behandeling.<\/p>\n\n\n\n
\u201cDie feit dat adolessente met TB na suksesvolle behandeling algehele laer longfunksie het in vergelyking met hul eweknie\u00eb is kommerwekkend, want dit kan beteken dat hulle nie hul volle potensiaal sal kan bereik wanneer hulle volwassenheid bereik nie, met die daaropvolgende risiko om vroeg chroniese longsiekte te ontwikkel aan in die lewe. Studies het getoon dat selfs ligte inkorting van longfunksie geassosieer word met verhoogde risiko van hart- en longprobleme later in die lewe, of selfs voortydige dood. Gevolglik wys ons data dat adolessente wat TB gehad het die risiko loop om permanente langtermyn hart- en longprobleme te h\u00ea,\u201d waarsku Van der Zalm en kollegas.<\/p>\n\n\n\n
\u201cOns resultate toon dat adolessente dringend ingesluit moet word by studies wat die voorkoming en behandeling van tuberkulose-geassosieerde respiratoriese morbiditeit ondersoek; dit sluit die behoefte in om longgesondheid as \u2019n uitkoms binne tuberkulosebehandelingsproewe by adolessente te assesseer.\u201d.<\/span> Vir meer inligting, kontak vir prof. Marieke van der Zalm by 076 047 2982 of mariekevdzalm@sun.ac.za.<\/p>\n","protected":false},"excerpt":{"rendered":" Twee uit drie adolessente by wie pulmonale tuberkulose (TB) gediagnoseer is, ervaar longabnormaliteite selfs nadat hulle die behandeling vir di\u00e9 siekte suksesvol voltooi 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